Effects on metabolic homeostasis and the epigenome. The use of bisphenol a bpa in packaging has grown over the past 50 years despite concerns of its migration into packaged food and beverages, resulting in human exposure. Pmc free article geens t, roosens l, neels h, covaci a. Updated exposure assessment for bisphenol a bpa from the consumption of adult canned food new data on canned food and beverages 5 memorandum dated 54 2011, baileyhatwellmihalov to. No health risk for consumers from bisphenol a exposure the. Bpa is used primarily in making polycarbonate plastic and some epoxy resins. Bisphenol a bpa is an organic compound that is widely used in the production of polycarbonate plastic containers for food use, such as clear single use and multiple use drinks bottles. Bisphenol a bpa is a chemical produced in large quantities for use primarily in the production of polycarbonate plastics and epoxy resins. Bpa bisphenol a is a chemical used in certain food contact materials and first approved by fda in the early 1960s. The assessment of aquatic risks has shown that both investigated compounds. No health risk for consumers from bisphenol a exposure. Summary notes bisphenol a bpa is a widely used chemical in polycarbonate plastic and epoxy resins. Exposure analysis of bisphenol a in surface water systems in.
The experts concluded that current dietary exposure to bpa through food packaging uses is not expected to pose a health. High ecotoxicological risk for bpa was characterized. Food records were also collected on the days that urine samples were collected to further evaluate the relationship between diet and urinary bpa levels. Bpa or bisphenol a has been in the news over the past several years.
Indeed, urine concentration of total bpa in woman 29 of the cohort of 29 pregnant women is equal to 74542 ngml, far higher than the concentration in pregnant woman 15, determined at a level of 33. Welshons5 1tufts university sackler school of graduate biomedical sciences, boston ma 02111 2department of environmental health, harvard school of public health, boston, ma 02115 3emory university, rollins school of public health, atlanta, ga 30322. Health canadas updated assessment of bisphenol a bpa. Bisphenol a bpa current state of knowledge and future. Global assessment of bisphenol a in the environment. Assessment of daily human exposure to bpa in the general population by biomonitoring of urinary excretion of bpa metabolites also varies widely, but has been estimated to be up to 0. We hope you will agree that the results of this indepth study and intensive cooperation will make a worthwhile contribution to the community objective of reducing the overall risks from exposure to chemicals. Variability and predictors of urinary bisphenol a concentrations during pregnancy.
Scientific opinion on bisphenol a 2015 efsa explains the safety of bisphenol a bpa poses no health risk to consumers because cur rent exposure to the chemical is too low to cause harm. This opinion describes the assessment of the risks to public health associated with bisphenol a bpa exposure. Specifically, the only research that vom saal and hughes cited as evidence relating bpa to disease is a study by takeuchi et al. In recent years, concerns have been raised about bpas safety. Health canada in september 2012, health canada released an updated assessment of bpa. Background on human health and environmental risk assessment.
Bisphenol a and related compounds in dental materials. Office of health assessment and translation ohat division of the national toxicology p rogram. Jan 05, 2017 bpa or bisphenol a has been in the news over the past several years. Quantitative estimate of carcinogenic risk from oral exposure pdf 8 pp, 93 k. Distribution and preliminary exposure assessment of. The exposure assessment and qualitative and quantitative information from the toxicological profile. Bisphenol a, part 2 recommendations for risk management rivm. Many studies have reported tumorigenic effects and endocrine alterations associated with bpa in animal models.
Ecotoxicogenomics to support ecological risk assessment. Diet is considered the primary source of bpa exposure, due to the use of bpa in polycarbonate plastics and epoxy resins used in food packaging. Bisphenol af bpaf is considered a new bisphenol analogue which is used as raw material in plastic industry, but little is known about its occurrence in the environment and the potential associated risk. Bpa is additionally used in many other consumer goods such as thermal receipt paper to be banned in the eu from 2020, toys and. Bisphenol a bpa is an organic synthetic compound with the chemical formula ch 3 2 cc 6 h 4 oh 2 belonging to the group of diphenylmethane derivatives and bisphenols, with two hydroxyphenyl groups. Asimakopoulos a adrian covaci c bondi gevao d boris johnsonrestrepo e taha a. See epas about pdf page to learn more bisphenol a bpa summary pdf 22 pp, 214 k, march, 2010. Based on the results of the lifetime exposure cancer bioassays conducted by the u. Comparison of bisphenol a and bisphenol s percutaneous. Fleisch af, sheffield pe, chinn c, edelstein bl, landrigan pj. Childrens environmental health and disease prevention research centers meeting. This iris assessment for bisphenol a consists of hazard identification and doseresponse assessment data and.
Polycarbonate plastics have many applications including use in some food and drink packaging, e. Bpa was positive in 73% of canned food samples, but was found in only 7% of noncanned foods at low concentrations. Human safety assessment of bisphenol a page 5 oral exposure to the human population including sensitive subgroups that is likely to be without an appreciable risk of deleterious effects during a lifetime epa, 1993. A multimedia assessment of the environmental fate of bisphenol a. This risk assessment improves our knowledge about the risks to human health and the environment from exposure to chemicals. Who toxicological and health aspects of bisphenol a. Reprinted with the permission of the holder, amherst scientific publishers. Bisphenol a exposure assessment from olive oil consumption. Based on new data and methodologies, efsa has lowered the estimated safe level, known as the tolerable daily intake tdi, to 4 micrograms per kilogram of body weight per day. The draft fda assessment of bisphenol a for use in food contact applications identifies the data and methods used to develop an exposure assessment and a toxicological profile.
Looking carefully at individual data, determination of bpa in urine does not provide the same exposure assessment as determination of total bpa. Assessment of human exposure to bisphenola, triclosan and tetrabromobisphenola through indoor dust intake in belgium. Request pdf bisphenol a exposure assessment from olive oil consumption the use of bisphenol a bpa in packaging has grown over the. Issuance of safe use determination for exposures to bisphenol. You may need a pdf reader to view some of the files on this page. Pdf one of chemical found ubiquitously in our environment, bisphenol a bpa, has received a tremendous amount of attention from.
The plastic monomer and plasticizer bisphenol a bpa is one of the highest volume chemicals produced worldwide, with over six billion pounds produced each year. Exposure assessment of adult intake of bisphenol a bpa with. Health canada last updated its risk assessment associated with bisphenol a bpa used in food packaging applications in august 2008. In toddler food, bpa concentrations were approximately 1 gkg on average.
Increasing attention has been paid to bisphenol a and bisphenol bp analogues due to high production volumes, wide usage and potential adverse effects. For adult foods, 30 studies representing about samples from several countries were available, and the data were segregated according to food type. Ecotoxicological risk assessment due to the presence of bisphenol a. Occurrence of bisphenol a in surface water, drinking water and plasma from malaysia with exposure assessment from consumption of drinking water. The 2015 efsa opinion highlighted an incomplete understanding of the effects of bpa on various toxicological outcomes, including effects on the.
Exposure was assessed for various groups of the human population in three different ways. Bisphenol a, public consultation, exposure assessment, toxicity, health risks, tdi 1 on request from efsa, question no efsa q20 00700 and no efsa 2014 00048, approved on 19 january 2015. Several areas of uncertainty remain in the risk assessment of bpa. Exposure assessment of adult intake of bisphenol a bpa. Assessment of daily human exposure to bpa in the general population by biomonitoring of urinary excretion of bpa metabolites also varies. Bpa is also used in the internal coatings of some food and beverage cans. Issuance of safe use determination for exposures to. This study aims at assessing human exposure to bpa from olive oil. This document describes the food and drug administrations fda safety assessment of bisphenol a bpa as it relates to exposure through use in food contact materials. For example, bpa is used in polycarbonate plastics, a high performance transparent, rigid plastic. Bisphenol a bpa is a chemical that is mainly used in combination with other chemicals to manufacture plastics and resins.
National institute of environmental health sciences. Pdf environmental risk assessment of bisphenol a and its. Exposure assessment of adult intake of bisphenol a bpa with emphasis on canned food dietary exposures. Science of the total environment 2012, 427428, 332338. Concerns about bpa and the potential effects of its widespread use in commercial everyday products, including. Polycarbonate is used to make food containers, such as reusable beverage bottles, tableware plates and mugs and storage containers.
Bisphenol a bpa summary assessing and managing chemicals. No health risk for consumers from bisphenol a exposure the bfr endorses the conclusion of the new efsa assessment. Nov 14, 2012 increasing attention has been paid to bisphenol a and bisphenol bp analogues due to high production volumes, wide usage and potential adverse effects. Prenatal bisphenol a exposure and early childhood behavior. Health risk of exposure to bisphenol a bpa article pdf available in roczniki panstwowego zakladu higieny 661. Office of health assessment and translation ohat division of the national toxicology p. It is a colorless solid that is soluble in organic solvents, but poorly soluble in water 0. At the time of that assessment, the department determined probable daily intakes pdi for bpa of 0.
Distribution and preliminary exposure assessment of bisphenol. This iris assessment for bisphenol a consists of hazard identification and doseresponse assessment data and provides support for epa risk management decisions. Exposure analysis of bisphenol a in surface water systems. A comparative assessment of human exposure to tetrabromobisphenol a and eight bisphenols including bisphenol a via indoor dust ingestion in twelve countries author links open overlay panel wei wang a khalid o. Bpa is used in the production of polycarbonate plastics, epoxy resins used to line metal cans, and in many plastic consumer products including toys, water pipes, drinking containers, eyeglass lenses, sports safety. What are the effects of bisphenol a on aquatic and soil organisms. Existing human research has major limitations and the cost of serum and urinary bpa assay remains a challenge in evaluating bpa exposure and. Predicted bpa exposure levels from the bpa exposure assessment module beam were compared to multiple spot urine samples. Due to the rapid and complete excretion of orally administered bisphenol a, urine samples are considered as the appropriate body fluid for bisphenol a exposure assessment. This assessment is particularly focused on the concerns for developmental toxicity identified in recent. In january 2015, the european food safety authority efsa published a new opinion on. Bpa is a white solid at room temperature with a molecular weight of 228. Welshons5 1tufts university sackler school of graduate biomedical sciences, boston ma 02111 2department of environmental health, harvard school of public health, boston, ma 02115. Review and analysis of its occurrence and bioaccumulation.